CBD (Cannabidiol) Interactions with Alprazolam

CBD Alprazolam Interactions

Is it safe to take CBD with Alprazolam? Xanax, one of the brand names for Alprazolam, is a strong drug that has serious side effects in its own right. Combine that with CBD (cannabidiol) and those side effects and others may present themselves.

All drugs can have potential interactions with other drugs. Before you decide to use CBD oil, or CBD in any form, in conjunction with any product containing Alprazolam, check with your medical professionals about any possible interactions.

In this article we have researched across the internet to see what authority sites say about interactions between Cannabidiol and Alprazolam products. At the bottom of this article you’ll find links to all of the sources we referenced when preparing this article.

What is Alprazolam?

Alprazolam is the active ingredient in drugs such as Alprazolam Intensol, Xanax, Niravam, Alprax, Kalma and Ralozam. Alprazolam belongs to a class of drugs called benzodiazepines. Alprazolam is used in the treatment of many conditions, including anxiety disorders, such as depression, panic disorder and generalized anxiety disorder (GAD) as well as insomnia, seizures and social phobias.

Alprazolam works by decreasing any abnormal activity in the brain.

Alprazolam Interactions

The risk of serious life-threatening side effects relating to breathing problems is high when Alprazolam is used with other medications, especially opiate medications. These medications are not necessarily prescribed medications and can include over-the-counter medications. Things you may take for pain or cough medicine and the like. Do not assume that interactions are only relevant to prescribed medications.

Alprazolam is known to interact with Cannabidiol with life threatening results.

How does CBD interact with Alprazolam?

The body breaks down Benzodiazepines (including Alprazolam) using P450 enzymes. CBD is a very strong inhibitor of the P450 enzymes. This means that CBD can affect how your body metabolizes Alprazolam by interfering with the P450 enzymes.

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As a consequence, the level of Alprazolam in your system increases. This then causes these potentially dangerous side effects. Add alcohol to this mix and these side effects can become extremely life threatening.

You should never mix alcohol with Alprazolam, ever, but the increased levels of Alprazolam in your system due to the use of CBD will drastically increase the life threatening risks.

Topical Versus Oral CBD Products

There is some discussion that using topical CBD is not a risk. The thought is that unlike oral CBD, topical CBD does not enter the blood stream and hence does not interfere with the P450 enzymes.

However, because the risks associated with mixing these drugs are potentially life threatening, you should always consult with you medical professionals before using any form of CBD.

What are the Symptoms?

There are many potential symptoms, but the common serious symptoms that you’re have a reaction to CBD include –

  • Dizziness
  • Lightheadedness
  • Extreme sleepiness
  • Changes in breathing
  • Unresponsiveness
  • Hallucinations
  • Severe skin rashes
  • Confusion and memory problems
  • Speech problems
  • Extreme changes in mood and temperament
  • Suicidal thoughts

If any of these present, seek immediate medical help.

What do I do?

If you’re considering using CBD (cannabidiol) products it is essential that you consult with your medical professionals first. Do not stop your medications before talking to the professionals. Tell them exactly what you are considering, remind them of your current medications and also any other medications such as herbs and vitamins you are taking. They will clarify any potential interactions and advise the best course of action. They may change the dose of your medications and should certainly monitor your progress.

Should your medical professionals decide that you can take CBD in conjunction with your Alprazolam medications, be sure you understand the symptoms, and advise your friends and family of the same. They may notice the symptoms before you, or in some cases you may not be capable of recognizing what is happening.

You must be aware of all medications that include Alprazolam, especially over-the-counter medications that your medical professionals won’t know you’re taking. Always advise your pharmacist you are taking CBD and inquire about any potential interactions with the product you’re considering taking.

Finally, because CBD oil may be able to treat those conditions for which you take Alprazolam, you should talk to your medical professionals about replacing Alprazolam with CBD. Because of the risk of addiction and other serious side effects of using Alprazolam, CBD oil may be a far better alternative, if it works for you.


Alprazolam (Wikipedia)
Alprazolam (MedlinePlus)
Drug Interactions Between Cannabis and Xanax (Drugs.com)
Is CBD Safe to Take with Zanax? (Michele Ross PhD)
CBD and Xanax: Can You Take Them Together? (CFAH)


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